Increase Font Size Decrease Font Size View as PDF Print
Search Plan and Results

Question(s)

What are the effects of maternal dietary intake of n-3 fatty acids from seafood on breast milk composition and health outcomes in infants? (DGAC 2010)

What are the effects of maternal dietary intake of n-3 fatty acids from seafood on breast milk composition and health outcomes in infants? (DGAC 2010)

Date Searched

08/20/2009; 08/24/2009; 10/08/2009

Inclusion Criteria

Subjects/Population

  • Age/Life stage: Pregnant or lactating women and infants
  • Health status: Healthy pregnant or lactating women and term infants
  • Nutrition related problem/Condition: Dietary intake of DHA.

Search Criteria

  • Study design preferences: RCT or clinical controlled studies, large non-randomized observational studies, meta-analysis and systematic reviews. Feeding period must be greater than four weeks
  • Size of study groups: The sample size must be more than 10 subjects for each study group. For example, this would include 10 patients in the intervention group and 10 patients in the control or comparison group
  • Study drop out rate: Less than 20%; preference for smaller dropout rates
  • Year range: 2000 to present
  • Languages: Limited to articles in English
  • Other: Article must be published in peer-reviewed journal.

Exclusion Criteria

Subjects/Population

  • Age: Non-pregnant or lactating adults, children and adolescents
  • Setting: Inpatients
  • Health status: Medical treatment, therapy, diseased subjects, malnourished or third-world populations
  • Nutrition related problem/condition: Supplemental DHA
  • Size of study groups: Sample sizes less than 10
  • Study designs: Cross-sectional; feeding periods less than four weeks
  • Study dropout rate: If the dropout rate in a study is 20% or greater
  • Year range: Prior to January 2000
  • Authorship: Studies by same author with similar in content and health outcome measurements
  • Languages: Articles not in English
  • Other: Animal studies; abstracts or presentations. 

Search Terms & Electronic Databases Used

 

  • “DHA” OR “FISH OIL” OR “N-3 LONG CHAIN POLYUNSATURATED FATTY ACID (LCPUFA)” AND “PREGNANCY” AND “HEALTH OUTCOMES” AND “INFANT”
  • “DHA” OR “FISH OIL” OR “N-3 LONG CHAIN POLYUNSATURATED FATTY ACID (LCPUFA)” AND “PREGNANCY” AND “DURATION”
  • “DHA” OR “FISH OIL” OR “N-3 LONG CHAIN POLYUNSATURATED FATTY ACID (LCPUFA)” AND “PREGNANCY” AND “PREMATURE BIRTH”
  • “DHA” OR “FISH OIL” OR “N-3 LONG CHAIN POLYUNSATURATED FATTY ACID (LCPUFA)” AND “PREGNANCY” AND “INTRAUTERINE GROWTH RETARDATION”
  • “DHA” OR “FISH OIL” OR “N-3 LONG CHAIN POLYUNSATURATED FATTY ACID (LCPUFA)” AND “PREGNANCY” AND “INFANT” AND “NEUROLOGICAL”
  • “DHA” OR “FISH OIL” OR “N-3 LONG CHAIN POLYUNSATURATED FATTY ACID (LCPUFA)” AND “PREGNANCY” AND “INFANT” AND “COGNITIVE”
  • “DHA” OR “FISH OIL” OR “N-3 LONG CHAIN POLYUNSATURATED FATTY ACID (LCPUFA)” AND “PREGNANCY” AND “INFANT” AND “VISION”
  • “DHA” OR “FISH OIL” OR “N-3 LONG CHAIN POLYUNSATURATED FATTY ACID (LCPUFA)” AND “LACTATION” OR “BREASTFEEDING” AND “INFANT” AND “NEUROLOGICAL”
  • “DHA” OR “FISH OIL” OR “N-3 LONG CHAIN POLYUNSATURATED FATTY ACID (LCPUFA)” AND “LACTATION” OR “BREASTFEEDING” AND “INFANT” AND “COGNITIVE”
  • “DHA” OR “FISH OIL” OR “N-3 LONG CHAIN POLYUNSATURATED FATTY ACID (LCPUFA)” AND “LACTATION” OR “BREASTFEEDING” AND “INFANT” AND “VISION”
  • “DHA” OR “FISH OIL” OR “N-3 LONG CHAIN POLYUNSATURATED FATTY ACID (LCPUFA)” AND “INFANT FORMULA” AND “INFANT” AND “NEUROLOGICAL”
  • “DHA” OR “FISH OIL” OR “N-3 LONG CHAIN POLYUNSATURATED FATTY ACID (LCPUFA)” AND “INFANT FORMULA” AND “INFANT” AND “COGNITIVE”
  • “DHA” OR “FISH OIL” OR “N-3 LONG CHAIN POLYUNSATURATED FATTY ACID (LCPUFA)” AND “INFANT FORMULA”  AND “INFANT” AND “VISION”

ADA Evidence Library

Total hits from all electronic database searches: 198

Total articles identified to review from electronic databases: 50

Articles identified via handsearch or other means:

Hand Search

 


Summary of Articles Identified to Review

Number of Primary Articles Identified: 8

Number of Review Articles Identified: 1

Total Number of Articles Identified: 9

Number of Articles Reviewed but Excluded: 41

 




List of Included Articles for Evidence Analysis

Systematic Reviews/Meta-Analysis

Brenna JT, B. Varamini, R.G. Jensen, D.A. Diersen-Schade, J.A. Boettcher and L.M. Arterburn. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007; 85: 1, 457–1, 464. View Record in Scopus

Primary Articles

Colombo J, Kannass KN, Shaddy DJ, Kundurthi S, Maikranz JM, Anderson CJ, Blaga OM, Carlson SE. Maternal DHA and the development of attention in infancy and toddlerhood. Child Dev. 2004 Jul-Aug; 75(4): 1, 254-1, 267. PMID: 15260876.

Drouillet P, Kaminski M, De Lauzon-Guillain B, Forhan A, Ducimetière P, Schweitzer M, Magnin G, Goua V,   Thiébaugeorges O, Charles MA. Association between maternal seafood consumption before pregnancy and fetal growth: Evidence for an association in overweight women. The EDEN mother-child cohort. Paediatr Perinat Epidemiol. 2009 Jan; 23(1): 76-86. PMID: 19228317. 

Hibbeln JR, Davis JM, Steer C, Emmett P, Rogers I, Williams C, Golding J. Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): An observational cohort study. Lancet. 2007 Feb 17; 369(9561): 578-585. PMID: 17307104.

Innis SM, Gilley J, Werker J. Are human milk long-chain polyunsaturated fatty acids related to visual and neural development in breast-fed term infants? J Pediatr. 2001 Oct; 139(4): 532-538.

Oken E, Radesky JS, Wright RO, Bellinger DC, Amarasiriwardena CJ, Kleinman KP, Hu H, Gillman MW. Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort. Am J Epidemiol. 2008 May 15; 167(10): 1, 171-1, 181. Epub 2008 Mar 18. PMID: 18353804. 

Oken E, Østerdal ML, Gillman MW, Knudsen VK, Halldorsson TI, Strøm M, Bellinger DC, Hadders-Algra M, Michaelsen KF, Olsen SF. Associations of maternal fish intake during pregnancy and breastfeeding duration with attainment of developmental milestones in early childhood: a study from the Danish National Birth Cohort. Am J Clin Nutr. 2008 Sep; 88(3): 789-796. PMID: 18779297.

Oken E, Wright RO, Kleinman KP, Bellinger D, Amarasiriwardena CJ, Hu H, Rich-Edwards JW, Gillman MW. Maternal fish consumption, hair mercury, and infant cognition in a U.S. Cohort. Environ Health Perspect. 2005 Oct; 113(10): 1, 376-1, 380. PMID: 16203250.

Olsen SF, Østerdal ML, Salvig JD, Kesmodel U, Henriksen TB, Hedegaard M, Secher NJ. Duration of pregnancy in relation to seafood intake during early and mid pregnancy: Prospective cohort. Eur J Epidemiol. 2006; 21(10): 749-758. Epub 2006 Nov 17. PMID: 17111251.

 

 


List of Excluded Articles with Reason